When it first started happening I contacted Alienware Support, who suggested that I run some tests to rule out hardware. The tests suggested that my CPU (Threadripper 16-Cores) and my GPU (1080ti) were functioning fine. I've been monitoring my GPU/CPU/RAM with task manager and noticed that right around when it started happening, my RAM (32GB) would jump to like 97%, and the emitter wouldn't even want to start pushing out particles...It would just hang at frame 0.
I tweaked the cell size and it started working perfectly but shortly after, it started crashing again

EDIT: I never ended up quite figuring out what caused the issue. Since then I've experienced some other weird hiccups that seemed to have something to do with my RAM. Hopefully i'll be able to narrow it down in the future.